专家人才库数据--The Xinjiang Technical Institute of Physics & Chemistry.CAS

Xin Xuelei, Female, Han, she was born in 1971and now are professor and Doctoral supervisor of the Resource Chemistry Research Office of Xinjiang Technology Institute of physical and chemical, Chinese Academy of Sciences. She has long been engaged in the study of the material basis and function of the efficacy of ethnic medicines, and has rich experience in structure identification, biological activity screening and mechanism research. She published 86 research papers, including 52 papers were collected in SCI, and wrote 3 chapters in English in advanced research monograph; Applied for 60 invention patents, authorized 41, and 6 of them were transferred, 22 students had got their master or doctor degree, 2 of them won national scholarships.

Research Areas and Achievements：

Focusing on the improvement of the scientific connotation of ethnic medicine for a long time, She has participated in the research on the material basis of more than 20 kinds of medicinal which common used in Uygur medicine, identified more than 300 compounds, including 6 new skeleton types and more than 60 new compounds, a number of characteristic components related to drug efficacy were found, which laid a foundation for the construction of its standardization system. The screening model of cholesterol lowering active ingredients has obtained national patents, and the screening model of lipid-lowering, hypoglycemic and anti-inflammatory were utilized, 28 active components and monomers were obtained through more than 4000 screening, and the hypoglycemic mechanism of 18 components or monomers was revealed, which provided support for revealing the scientific nature of traditional uses of ethnic medicines. Two national standard sample certificates have been obtained, of which the standard of Lactucin has been used in the quality control of medicine and products which include Cichorium glandulosum, all of these work accelerate the standardization process of ethnic medicines; Participated in the research and transformation of the first new Medicine of effective part of traditional Chinese medicine- total flavone tablets of cotton flower in Xinjiang and Nazilai granules, the technical of them were transferred to local pharmaceutical companies, and providing a demonstration for the development of innovative drugs for ethnic medicine. As the deputy director of the key laboratory, she participated in the establishment of the provincial and ministerial joint construction of the cultivation base of the State Key Laboratory for the util ization of unique medicinal resources in Xinjiang and the Key Laboratory of plant resource chemistry in arid areas of the Chinese Academy of Sciences, which have become important bases for the research and development of ethnic medicines and the cultivation of talents.

Main Honor：

3 first prizes, 3 second prizes, 1 third prize of Xinjiang Science and Technology Progress Award, and 2 second prizes for excellent natural science papers in Xinjiang were obtained; selected into Tianshan talent project for two times; the outstanding contribution award of Wang Kuancheng western scholar of the Chinese Academy of Sciences and the title of excellent female worker of Xinjiang Education trade union were obtained.

Representative Publications：

1. Duan, X., Li, J., Cui, J., Li, H., Hasan, B*., Xin, X*., Chemical component and in vitro protective effects of Matricaria chamomilla (L.) against lipopolysaccharide insult, Journal of Ethnopharmacology 2022, doi: https://doi.org/10.1016/j.jep.2022.115471.(IF =

2. Yin, Q.; Abdulla, R.; Kahar, G.; Aisa, H.A.; Li, C*.; Xin, X*. Mass Defect Filtering-Oriented Identification of Resin Glycosides from Root of Convolvulus scammonia Based on Quadrupole-Orbitrap Mass Spectrometer. Molecules 2022, 27, 3638. https://doi.org/10.3390/ molecules27113638

3. Liu Changhua , Wahefu Atikanmu, Lu Xueying，Abdulla Rahima，Dou Jun，Zhao Haiqing，Aisa Haji Akber， Xin Xuelei^* , and Liu Yongqiang^* Chemical Profiling of Kaliziri Injection and Quantification of Six Caffeoyl Quinic Acids in Beagle Plasma by LC-MS/MS Pharmaceuticals 2022, 15, 663. https://doi.org/10.3390/ ph15060663

4. Xiao Yan Liu, Jun Peng Fei He, Xirali Tursun，Shu Ping Li, Xue Lei Xin^* and Haji Akber Aisa* Shabyar Ameliorates High Glucose Induced Retinal Pigment Epithelium Injury Through Suppressing Aldose Reductase and AMPK/mTOR/ULK1 Autophagy Pathway Front. Pharmacol., 2022， 13:852945. https://doi.org/10.3389/fphar.2022.852945

5. Xiaomei Duan，Jun Li，Jingxue Cui, Yuwei Dong，Xuelei Xin*，Haji Akber Aisa* Anti-inflammatory activity of Anchusa italica Retz. in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways Journal of Ethnopharmacology 2022, 286: 114899

6. Xiaoqin Xu, Juan Zhang, Liang Chen, Yu Sun, Degang Qing, Xuelei Xin*, Chunyan Yan Alhagi pseudalhagi Extract Exerts Protective Effects Against Intestinal Inflammation in Ulcerative Colitis by Affecting TLR4-Dependent NF-κB Signaling Pathways Front. Pharmacol. 12:764602. doi: 10.3389/fphar.2021.764602

7. Salamet Edirs, Lan Jiang, XueLei Xin* and Haji Akber Aisa* Kursi Wufarikun Ziyabit Improves the Physiological Changes by Regulating Endoplasmic Reticulum Stress in the Type 2 Diabetes db/db Mice Evidence-Based Complementary and Alternative Medicine Volume 2021, Article ID 2100128, 10 pages https://doi.org/10.1155/2021/2100128

8. Ma Ye, Li Jun, Tong Fei, Xin Xue-Lei,*, Aisa Haji Akber,* Optimization of microwave-assisted extraction using response surface methodology and the potential anti-diabetic efficacy of Nigella glandulifera Freyn determined using the spectrum–effect relationship Industrial Crops & Products 2020，153： 112592

9. Tang Dan , Liu Liu , Ajiakber Dildar , Ye Jianping , Xu Jianjun , Xin Xuelei*and Aisa Haji Akber * Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3β and Inhibition of IRE1α-XBP1 Pathways Front. Endocrinol. 2018，9: 586. https://doi: 10.3389/fendo.2018.00586

10. Liu Liu, Mireguli Yasen, Dan Tang, Jianping Ye, Haji Akber Aisa Xuelei Xin* Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway Biomed. Pharmacother 2018, 100;29-35

Patents：

1. Xin Xuelei, Hu Miao, Mahinur, Sodik, Maidina, Haji Akber Aisa The usage of n-butyl alcohol extract of Anaphalis virgata Patent No.: ZL202011238159.9

2. Xin Xuelei, Hu Miao, Mahinur, Sodik, Maidina, Haji Akber Aisa The usage of an ethyl acetate extract from Achillea filipendulina Patent No.: ZL202011244026.2

3. Xin Xuelei, Peng Jun, Liu Xiaoyan, Haji Akber Aisa, He Fei The usage of polyphenol from Apocynum venetum leaf Patent No.: ZL201911098521.4

4. Xin Xuelei, Wu heting, Haji Akber Aisa, Senawar Munsel The usage of safflower extract with clear spectrum effect relationship. Patent No.: ZL201610282102.6

5. Xin Xuelei, Salamaiti Aidisre, Xie Lianzhen, Haji Akber Aisa. The preparation method and usage of the hypoglycemic effective part from safflower seed meal Patent No.: ZL20150077369.7

6. Xin Xuelei, Xie Lianzhen, Chen Qibin, Haji Akber Aisa. The usage of the ethyl acetate part of seed of Nigella glandulifera Patent No.: 201510073001.3

7. Xinxuelei; Chen Qibin; Haji Akber Aisa.; The preparation of Alkaloids with skeleton type 1 in the seeds of Nigella glandulifera Patent No.: ZL201310046399.2

8. Xinxuelei; Chen Qibin; Haji Akber Aisa.; The preparation of Alkaloids with skeleton type II in the seeds of Nigella glandulifera Patent No.: ZL201310046468.X

9. Xinxuelei; Chen Qibin; Haji Akber Aisa.; The usage of Alkaloids with skeleton type 1 and II in the seeds of Nigella glandulifera Patent No.: ZL 201310217003.6

10. Haji Akber Aisa; Xin Xue Lei; Liu Xixi; The preparation methods and usage of ester compounds from seed of Nigella glandulifera Patent No.: ZL201710622006.6

Field of research：

Chemistry of Traditional Chinese medicine and ethnopharmacology