Xuelei XIN, Female, Han, was born in 1971. She is currently a Professor and Doctoral Supervisor of the Resource Chemistry Research Office, Xinjiang Institute of Physical and Chemical Technology, Chinese Academy of Sciences. She has long been engaged in the study of the material basis and function of the efficacy of ethnic medicines, and has rich experience in structure identification, biological activity screening and mechanism research. She published eighty-six research papers, among which fifty-two papers were collected in SCI, and wrote three English chapters in advanced research monographs. She applied for sixty invention patents, forty-one of which were authorized, and six of them were transferred. She has guided twenty-two students to obtain their master or doctor degree, two of whom won national scholarships.
Research Areas and Achievements:
Focusing on the improvement of the scientific connotation of ethnic medicine for a long time, she has participated in the research on the material basis of more than twenty kinds of medicinal materials commonly used in Uygur medicine, identified more than three hundred compounds, including six new skeleton types and more than sixty new compounds. A number of characteristic components related to drug efficacy were found, which laid a foundation for the construction of its standardization system. The screening model of cholesterol lowering active ingredients has obtained national patents, and the screening models of lipid-lowering, hypoglycemic and anti-inflammatory ingredients were adopted. Twenty-eight active components and monomers were obtained through more than four thousand screenings, and the hypoglycemic mechanism of eighteen components or monomers was revealed, which provided support for revealing the scientific nature of traditional uses of ethnic medicines. Two national standard sample certificates have been obtained, of which the standard of Lactucin has been used in the quality control of medicines and products containing Cichorium glandulosum; all of these works accelerate the standardization process of ethnic medicines. She participated in the research and transformation of the first new medicine of effective part of traditional Chinese medicine in Xinjiang — total flavone tablets of cotton flower and Nazilai granules. Their technologies were transferred to local pharmaceutical companies, providing a demonstration for the development of innovative drugs for ethnic medicine. As the deputy director of the key laboratory, she participated in the establishment of the provincial and ministerial joint cultivation base of the State Key Laboratory for the Utilization of Unique Medicinal Resources in Xinjiang and the Key Laboratory of Plant Resource Chemistry in Arid Areas of the Chinese Academy of Sciences, which have become important bases for the research and development of ethnic medicines and talent cultivation.
Main Honors:
She obtained three first prizes, three second prizes and one third prize of Xinjiang Science and Technology Progress Award, as well as two second prizes for excellent natural science papers in Xinjiang. She was selected into the Tianshan Talent Project two times, and won the Outstanding Contribution Award of Wang Kuancheng Western Scholar of the Chinese Academy of Sciences and the title of Excellent Female Worker of Xinjiang Education Trade Union.
Representative Publications:
Duan, X., Li, J., Cui, J., Li, H., Hasan, B., XIN, X.* Chemical component and in vitro protective effects of Matricaria chamomilla (L.) against lipopolysaccharide insult. Journal of Ethnopharmacology, 2022, doi: https://doi.org/10.1016/j.jep.2022.115471.
Yin, Q., Abdulla, R., Kahar, G., Aisa, H.A., Li, C., XIN, X. Mass Defect Filtering-Oriented Identification of Resin Glycosides from Root of Convolvulus scammonia Based on Quadrupole-Orbitrap Mass Spectrometer. Molecules, 2022, 27, 3638. https://doi.org/10.3390/molecules27113638
Liu, C.H., Wahefu, A., Lu, X.Y., Abdulla, R., Dou, J., Zhao, H.Q., Aisa, H.A., XIN, X.L., Liu, Y.Q. Chemical Profiling of Kaliziri Injection and Quantification of six Caffeoyl Quinic Acids in Beagle Plasma by LC-MS/MS. Pharmaceuticals, 2022, 15, 663. https://doi.org/10.3390/ph15060663
Liu, X.Y., He, J.P.F., Tursun, X., Li, S.P., XIN, X.L., Aisa, H.A. Shabyar Ameliorates High Glucose Induced Retinal Pigment Epithelium Injury Through Suppressing Aldose Reductase and AMPK/mTOR/ULK1 Autophagy Pathway. Front. Pharmacol., 2022, 13: 852945. https://doi.org/10.3389/fphar.2022.852945
Duan, X.M., Li, J., Cui, J.X., Dong, Y.W., XIN, X.L., Aisa, H.A. Anti-inflammatory activity of Anchusa italica Retz. in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways. Journal of Ethnopharmacology, 2022, 286: 114899
Xu, X.Q., Zhang, J., Chen, L., Sun, Y., Qing, D.G., XIN, X.L., Yan, C.Y. Alhagi pseudalhagi Extract Exerts Protective Effects Against Intestinal Inflammation in Ulcerative Colitis by Affecting TLR4-Dependent NF-κB Signaling Pathways. Front. Pharmacol., 2021, 12: 764602. doi: 10.3389/fphar.2021.764602
Edirs, S., Jiang, L., XIN, X.L., Aisa, H.A. Kursi Wufarikun Ziyabit Improves the Physiological Changes by Regulating Endoplasmic Reticulum Stress in the Type 2 Diabetes db/db Mice. Evidence-Based Complementary and Alternative Medicine, Volume 2021, Article ID 2100128, ten pages. https://doi.org/10.1155/2021/2100128
Ma, Y., Li, J., Tong, F., XIN, X.L., Aisa, H.A. Optimization of microwave-assisted extraction using response surface methodology and the potential anti-diabetic efficacy of Nigella glandulifera Freyn determined using the spectrum–effect relationship. Industrial Crops & Products, 2020, 153: 112592
Tang, D., Liu, L., Dildar, A., Ye, J.P., Xu, J.J., XIN, X.L., Aisa, H.A. Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3β and Inhibition of IRE1α-XBP1 Pathways. Front. Endocrinol., 2018, 9: 586. https://doi: 10.3389/fendo.2018.00586
Liu, L., Yasen, M., Tang, D., Ye, J.P., Aisa, H.A., XIN, X.L. Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway. Biomed. Pharmacother., 2018, 100: 29-35
Patents:
XIN, X.L., Hu, M., Mahinur, Sodik, Maidina, Aisa, H.A. The usage of n-butyl alcohol extract of Anaphalis virgata. Patent No.: ZL202011238159.9
XIN, X.L., Hu, M., Mahinur, Sodik, Maidina, Aisa, H.A. The usage of an ethyl acetate extract from Achillea filipendulina. Patent No.: ZL202011244026.2
XIN, X.L., Peng, J., Liu, X.Y., Aisa, H.A., He, F. The usage of polyphenol from Apocynum venetum leaf. Patent No.: ZL201911098521.4
XIN, X.L., Wu, H.T., Aisa, H.A., Munsel, S. The usage of safflower extract with clear spectrum effect relationship. Patent No.: ZL201610282102.6
XIN, X.L., Aidisre, S., Xie, L.Z., Aisa, H.A. The preparation method and usage of the hypoglycemic effective part from safflower seed meal. Patent No.: ZL20150077369.7
XIN, X.L., Xie, L.Z., Chen, Q.B., Aisa, H.A. The usage of the ethyl acetate part of seed of Nigella glandulifera. Patent No.: 201510073001.3
XIN, X.L., Chen, Q.B., Aisa, H.A. The preparation of Alkaloids with skeleton type I in the seeds of Nigella glandulifera. Patent No.: ZL201310046399.2
XIN, X.L., Chen, Q.B., Aisa, H.A. The preparation of Alkaloids with skeleton type II in the seeds of Nigella glandulifera. Patent No.: ZL201310046468.X
XIN, X.L., Chen, Q.B., Aisa, H.A. The usage of Alkaloids with skeleton type I and II in the seeds of Nigella glandulifera. Patent No.: ZL 201310217003.6
Aisa, H.A., XIN, X.L., Liu, X.X. The preparation methods and usage of ester compounds from seed of Nigella glandulifera. Patent No.: ZL201710622006.6
Field of Research:
Chemistry of Traditional Chinese medicine and ethnopharmacology.
